In “Missing the Forest for the Trees: Aduhelm, Accelerated Approvals & the Agency,” Dr. Matthew Herder argues that agency capture and politicized discretion drive delays in confirmatory trials of accelerated approval drugs amongst other concerns at US Food and Drug Administration (FDA). In highlighting this important problem and offering nuanced insight into agency workings based in part on interviews with twenty-three unnamed FDA officials and a three-drug case study, Dr. Herder suggests two innovative solutions. However, amidst broader debates balancing agency (...) expertise, data, and delegation, these proposed policy solutions would benefit from more corroborative evidence and consideration of institutional advantages within constitutional limits. (shrink)

The COVID-19 pandemic has resulted in more than 524 million cases and 6 million deaths worldwide. Various drug interventions targeting multiple stages of COVID-19 pathogenesis can significantly reduce infection-related mortality. The current within-host mathematical modeling study addresses the optimal drug regimen and efficacy of combination therapies in the treatment of COVID-19. The drugs/interventions considered include Arbidol, Remdesivir, Interferon and Lopinavir/ritonavir. It is concluded that these drugs, when administered singly or in combination, reduce the number of infected cells and viral load. (...) Four scenarios dealing with the administration of a single drug, two drugs, three drugs and all four are discussed. In all these scenarios, the optimal drug regimen is proposed based on two methods. In the first method, these medical interventions are modeled as control interventions and a corresponding objective function and optimal control problem are formulated. In this framework, the optimal drug regimen is derived. Later, using the comparative effectiveness method, the optimal drug regimen is derived based on the basic reproduction number and viral load. The average number of infected cells and viral load decreased the most when all four drugs were used together. On the other hand, the average number of susceptible cells decreased the most when Arbidol was administered alone. The basic reproduction number and viral load decreased the most when all four interventions were used together, confirming the previously obtained finding of the optimal control problem. The results of this study can help physicians make decisions about the treatment of the life-threatening COVID-19 infection. (shrink)

It is proposed that there are important generalizations about problem solving in design activity that reach across specific disciplines. A framework for the study of design is presented that (a) characterizes design as a radial category and fleshes out the task environment of the prototypical cases; (b) takes the task environment seriously; (c) shows that this task environment occurs in design tasks, but does not occur in every nondesign task; (d) explicates the impact of this task environment on the design (...) problem space; and (e) demonstrates that, given the structure of the information-processing system, the features noted in the problem spaces of design tasks will not all occur in problem spaces where the task environment is vastly different. This analysis leads to the claim that there are a set of invariant features in the problem spaces of design situations that collectively constitute a design problem space. Protocol studies are reported in which the problem spaces of three design tasks in architecture, mechanical engineering, and instructional design are explored and compared with several protocols from nondesign problem-solving tasks. (shrink)

It is proposed that there are important generalizations about problem solving in design activity that reach across specific disciplines. A framework for the study of design is presented that (a) characterizes design as a radial category and fleshes out the task environment of the prototypical cases; (b) takes the task environment seriously; (c) shows that this task environment occurs in design tasks, but does not occur in every nondesign task; (d) explicates the impact of this task environment on the design (...) problem space; and (e) demonstrates that, given the structure of the information-processing system, the features noted in the problem spaces of design tasks will not all occur in problem spaces where the task environment is vastly different. This analysis leads to the claim that there are a set of invariant features in the problem spaces of design situations that collectively constitute a design problem space. Protocol studies are reported in which the problem spaces of three design tasks in architecture, mechanical engineering, and instructional design are explored and compared with several protocols from nondesign problem-solving tasks. (shrink)

This volume explores Nietzsche's decisive encounter with the ancient philosopher, Epicurus. The collected essays examine many previously unexplored and underappreciated convergences, and investigate how essential Epicurus was to Nietzsche's philosophical project through two interrelated overarching themes: nature and ethics. Uncovering the nature of Nietzsche's reception of, relation to, and movement beyond Epicurus, contributors provide insights into the relationship between suffering, health and philosophy in both thinkers; Nietzsche's stylistic analysis of Epicurus; the ethics of self-cultivation in Nietzsche's Epicureanism; practices of eating (...) and thinking in Nietzsche and Epicurus; the temporality of Epicurean pleasure; the practice of the gay science, and Epicureanism and politics. The essays also provide creative comparisons with the Stoics, Hobbes, Mill, Guyau, Buddhism, and more. Nietzsche and Epicurus offers original and illuminating perspectives on Nietzsche's relation to the Hellenistic thinker, in whom Nietzsche saw the embodiment of the practice of philosophy as an art of existing. (shrink)

It frequently happens in philosophy that a philosopher, in trying to resolve a long-standing dispute between two opposing schools of thought, comes up with a schema that not only resolves the targeted dispute, but in addition necessarily imposes a residual set of regulations and norms, to which it had to subscribe in its attempt to solve the dispute, given its own presuppositions and points of departure. This residual set of norms is then viewed by the subsequent generation of thinkers, who (...) start off their philosophy from a slightly different set of presuppositions, as being superfluous to what they conceive as the real project of the previous thinker. Hence, these subsequent philosophers build their philosophy by fundamentally modifying the stance of the previous thinker, all the while acknowledging the resolution of the dispute the latter carried out in his philosophy. One can view this process of fundamental shifts in orientation as the process of transition from one revolution to another in the history of philosophy. (shrink)

In matters of discontinuation of life-sustaining treatment, traditional role of the family to speak on behalf of the incompetent patient is questionable. We explore the reasons why physicians perceive patient autonomy to be transferrable to family members. Principle of patient autonomy may not suffice when futile treatment is demanded and may serve to erode the ethical integrity of medical profession. An enhanced role for bioethics committees is proposed when physicians propose to discontinue life-sustaining treatment against the wishes of the patient (...) or their families. (shrink)

We address Northcott’s criticism of Pearson’s correlation coefficient ‘r’ in measuring causal strength by replacing Pearson’s linear regressions by nonparametric nonlinear kernel regressions. Although new proof shows that Suppes’ intuitive causality condition is neither necessary nor sufficient, we resurrect Suppes’ probabilistic causality theory by using nonlinear tools. We use asymmetric generalized partial correlation coefficients from Vinod [2014] as our third criterion in addition to two more criteria. We aggregate the three criteria into one unanimity index, UI in [-100; 100], (...) quantifying causal strengths associated with causal paths: Xi -> Xj, Xj -> Xi, and Xi Xj. (shrink)

This article explores the influence of modernity in India, within the larger framework of state-led modernity and its impact on identity and locality. The discourse on modernity has retained the common thread of transience and reflexivity as two constitutive features, both of which are taken up to explain the uncertain and provisional influence of modernity on the Indian society and identity, and the radical engagement of social movements with modernity. The article studies the complex functioning of modernity in India by (...) presenting a theoretical outline on the contested nature of the concept, with an emphasis on the discussion around reflexivity, which forms one of the core attributes for the creation of multiple and alternative modernities, by reviewing state-led modernity in India and its impact on identity formation as a consequence of the numerous and variable cultural and value systems that confront individuals and by looking at the local appropriation of contested spaces to enter into a radical, value-based engagement with global modernity. (shrink)

Although deductive reasoning is a closed system, one's beliefs about the world can influence validity judgements. To understand the associated functional neuroanatomy of this belief-bias we studied 14 volunteers using event-related fMRI, as they performed reasoning tasks under neutral, facilitatory and inhibitory belief conditions. We found evidence for the engagement of a left temporal lobe system during belief-based reasoning and a bilateral parietal lobe system during belief-neutral reasoning. Activation of right lateral prefrontal cortex was evident when subjects inhibited a prepotent (...) response associated with belief-bias and correctly completed a logical task, a finding consistent with its putative role in cognitive monitoring. By contrast, when logical reasoning was overcome by belief-bias, there was engagement of ventral medial prefrontal cortex, a region implicated in affective processing. This latter involvement suggests that belief-bias effects in reasoning may be mediated through an influence of emotional processes on reasoning. (shrink)

The goal of this article is to trace the transformations in Nietzsche's early thinking that led to the ideas published in Human, All Too Human, the first book of his mature philosophy. In contrast to his early works, in which he sides with art and philosophy in criticizing the scientific culture of his time, Nietzsche, in Human, All Too Human, hails the methodology of science as a way to overcome the metaphysical delusions of philosophy, art, and religion. However, in disagreement (...) with popular scholarly view, I show that Human, All Too Human does not represent a complete break with his earlier writings, but rather a shift in emphasis. I argue that the overall project connecting Nietzsche's early thought to Human, All Too Human is, first, the attempt to come to terms with the upheavals introduced into the cultural terrain by the Socratic turn, and second, to affirm a higher culture. (shrink)

A key question for cognitive theories of reasoning is whether logical reasoning is inherently a sentential linguistic process or a process requiring spatial manipulation and search. We addressed this question in an event-related fMRI study of syllogistic reasoning, using sentences with and without semantic content. Our findings indicate involvement of two dissociable networks in deductive reasoning. During content-based reasoning a left hemisphere temporal system was recruited. By contrast, a formally identical reasoning task, which lacked semantic content, activated a parietal system. (...) The two systems share common components in bilateral basal ganglia nuclei, right cerebellum, bilateral fusiform gyri, and left prefrontal cortex. We conclude that syllogistic reasoning is implemented in two distinct systems whose engagement is primarily a function of the presence or absence of semantic content. Furthermore, when a logical argument results in a belief–logic conflict, the nature of the reasoning process is changed by recruitment of the right prefrontal cortex. (shrink)

Paul Raimond Daniels’s Nietzsche and The Birth of Tragedy is an engaging, instructive, and clearly written study of Nietzsche’s first book. It is a particularly fine achievement given the difficulties, in terms of both style and content, that Nietzsche’s text presents to the reader. Daniels’s aim is to present BT as an ideal introduction to Nietzsche’s philosophy, and, in light of its problematizing of the relation between art and truth, to argue that BT is crucial for evaluating the aims, successes, (...) and shortcomings of Nietzsche’s later philosophy. Furthermore, Daniels presents an “affirmative” interpretation, arguing that BT champions a life-affirming worldview that finds its highest expression in... (shrink)

Two recent works will be considered that discuss Heidegger and Nietzsche in the context of the problem of overcoming metaphysics and the onto-theological tradition. A common criticism will be that these works in their attempt to retrieve a conception of religion, politics or faith beyond onto-theology and metaphysics tend to justify or idealize particular historically and culturally conditioned perspectives, which are not immune from further philosophical critique. Simon Oliai’s approach to countering the burgeoning fundamentalisms in our global age is ultimately (...) not very convincing, representing as it does, a Western, liberal, Eurocentric worldview. The author’s use of Nietzsche or Heidegger for this purpose is also not very compelling. The remainder of this review essay appraises the volume edited by Cimino and van der Heiden, which attempts to rethink faith beyond onto-theology in several interesting ways. Although meant to be a comparative study, several contributions subscribe to a general Heideggerian (or Heidegger-inspired phenomenological-hermeneutical) theoretical framework, which itself is not rigorously scrutinized. A problematic implication is that Nietzsche’s own critical and constructive views of philosophy, his critique of religion and history, and his positive appraisal of faith and divinity are not seriously considered on their own terms: they are either mostly ignored, or they are selectively interpreted through a Heideggerian lens, with the result that this volume puts forward a mostly unfavorable view of Nietzsche. Some of the conceptual moves credited to Heidegger in the volume have their equivalents in Nietzsche’s philosophy, which a comparative and evaluative study such as this one must seriously take into account by resisting the uncritical acceptance of Heidegger’s own view of Nietzsche. (shrink)

This paper argues that for Nietzsche it is only when the strong type decays on its own terms that it is possible for a weak type to come into dominance by inverting the values of the strong. It sets right a latent inconsistency in Deleuze’s work, Nietzsche and Philosophy , which traces back the origin of decadence to the subterranean struggle between reactive forces. I show that Deleuze’s reading runs contrary to his own contention that for Nietzsche the negative is (...) a result of activity. I argue that the decadence of the strong is a consequence of its very creative activity and abundant health. Relying on Nietzsche’s later works, I isolate and analyze four typical traits of the strong type which not only determine this type as what it is but also make it vulnerable to decadence. (shrink)

Spirituality in the workplace is gaining recognition and value among researchers, academicians, and business professionals. The aim of this paper is to examine the impact of spirituality in the workplace on job satisfaction by measuring four dimensions of spirituality in the workplace: meaningful work, sense of community, organizational values, and compassion. The impact of each dimension on job satisfaction is hypothesized. A cross-sectional survey was used to collect data from 100 payroll employees in private insurance companies in Punjab. A correlation (...) analysis showed a positive relationship between all the dimensions of spirituality in the workplace and job satisfaction. A regression analysis revealed that although all the dimensions of spirituality in the workplace are important, organizational values and a sense of community are the most important in terms of the job satisfaction level of employees. This work will help insurance companies to better understand the concept of spirituality in the workplace and its importance. Insurance companies can improve their functioning by encouraging employee spirituality in the workplace. (shrink)

A substantial guide providing an overview of both physicalism and metaphysical naturalism, reviewing both questions of formulation and justification for both doctrines. Includes a diagnostic strategy for understanding talk of naturalism as a metaphysical thesis.

Many cognitive accounts of emotional processing assume that emotions have representational content that can be influenced by beliefs and desires. It is generally thought that emotions also have non-cognitive, affective components, including valence and arousal. To clarify the impact of cognition on these affective components we asked participants to rate sentences along cognitive and affective dimensions. For the former case, participants rated the believability of the material. For the latter case, they provided valence and arousal ratings. Across two experiments, we (...) show that valence and arousal are differently influenced by beliefs, suggesting that these two largely independent affective components of emotion differ in their cognitive penetrability. While both components depended upon overall comprehension of sentence meaning, only valence was influenced by the consistency of the sentences with participants’ beliefs (i.e., whether it was believable or unbelievable). We discuss the implications of these findings for understanding cognition–emotion relationships. (shrink)

Cognitive science uses the notion of computational information processing to explain cognitive information processing. Some philosophers have argued that anything can be described as doing computational information processing; if so, it is a vacuous notion for explanatory purposes.An attempt is made to explicate the notions of cognitive information processing and computational information processing and to specify the relationship between them. It is demonstrated that the resulting notion of computational information processing can only be realized in a restrictive class of dynamical (...) systems called physical notational systems (after Goodman's theory of notationality), and that the systems generally appealed to by cognitive science-physical symbol systems-are indeed such systems. Furthermore, it turns out that other alternative conceptions of computational information processing, Fodor's (1975) Language of Thought and Cummins' (1989) Interpretational Semantics appeal to substantially the same restrictive class of systems. (shrink)

This chapter explores the debate between contemporary projectivists or expressivists, and the advocates of sensibility theory. Both positions are best viewed as forms of sentimentalism — the theory that evaluative concepts must be explicated by appeal to the sentiments. It argues that the sophisticated interpretation of such notions as “true” and “objective” that are offered by defenders of these competing views ultimately undermines the significance of their meta-ethical disputes over “cognitivism” and “realism” about value. Their fundamental disagreement lies in moral (...) psychology; it concerns how best to understand the emotions to which sentimentalist theories must appeal. (shrink)

Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory and behavior studies. Devices capable of both recording and manipulating neuronal activity brain-computer interfaces should ideally operate un-tethered and allow chronic longitudinal manipulations in the freely moving animal. In this study, we designed a new intracortical BCI feasible of telemetric recording and stimulating local gray and white matter of visual neural circuit after irradiation exposure. To increase the translational reliance, we put forward a Göttingen minipig model. The (...) animal was stereotactically irradiated at the level of the visual cortex upon defining the target by a fused cerebral MRI and CT scan. A fully implantable neural telemetry system consisting of a 64 channel intracortical multielectrode array, a telemetry capsule, and an inductive rechargeable battery was then implanted into the visual cortex to record and manipulate local field potentials, and multi-unit activity. We achieved a 3-month stability of the functionality of the un-tethered BCI in terms of telemetric radio-communication, inductive battery charging, and device biocompatibility for 3 months. Finally, we could reliably record the local signature of sub- and suprathreshold neuronal activity in the visual cortex with high bandwidth without complications. The ability to wireless induction charging combined with the entirely implantable design, the rather high recording bandwidth, and the ability to record and stimulate simultaneously put forward a wireless BCI capable of long-term un-tethered real-time communication for causal preclinical circuit-based closed-loop interventions. (shrink)

A symbolic computer model, employing the perceptual strategy, is presented for solving Tower of Hanoi problems. The model is calibrated—in terms of the number of problems solved, time taken, and number of moves made—to the performance of 20 normal subjects. It is then “lesioned” by increasing the decay rate of elements in working memory to model the performance of 20 patients with lesions to the prefrontal cortex. The model captures both the main effects of subject groups (patients and normal controls) (...) performance, and the subject groups (patients and normal controls) by problem difficulty interactions. This leads us to support the working memory hypothesis of frontal lobe functions, but for a narrow range of problems. (shrink)

Inside What Would Plato Do?, you'll find the basics of philosophy, written in an easy, digestible way we can all understand, along with questions to help you apply these important theories to your own life. So, after you've learned about a philosophical concept, you'll then be challenged to test yourself and see how the results can impact your daily life. For instance, after learning about Kant's theory of morality and the importance of intention you're challenged with questions like: Can good (...) people do bad things? Was there a time when you intended to do something helpful that ended up being hurtful? Does that make you a good person (because you intended to do good) or a bad person (because the results were bad)? What Would Plato Do? will not only help you better understand some of the greatest thinkers ever but will also help you think of the world around you in a whole new way! (shrink)